4.5 Review

Solvent-Free Synthesis of Pyrroles: An Overview

Journal

ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue 9, Pages 2318-2333

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202100436

Keywords

Mechanochemical; Microwave-assisted reactions; One-pot synthesis; Pyrrole; Solvent-free

Funding

  1. Council of Scientific and Industrial Research (CSIR New Delhi)
  2. Kerala State Council for Science Technology & Environment (KSCSTE, Trivandrum) [341/2013/KSCSTE]

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Pyrroles are well-known scaffolds with wide applications in biological and pharmaceutical fields, and solvent-free synthesis of pyrroles has become an emerging area in organic synthesis. This review focuses on the literature covering solvent-free synthesis of pyrroles up to 2021.
Pyrroles are well known scaffolds having wide applications in biological and pharmaceutical field. It is a privileged heterocyclic scaffold present in many natural products, drug molecules, agrochemicals and has shown applications in material science. Solvent-free synthesis of pyrroles became an emerging area in organic synthesis. This review focuses on the solvent-free synthesis of pyrroles covering literature up to 2021.

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