Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue 11, Pages 2880-2882Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202100492
Keywords
Pd(II)-catalyzed; carbonylative; cyclization; molybdenum hexacarbonyl; pyrimidoquinazolinone
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Funding
- National Natural Science Foundation of China [21772236]
- Fundamental Research Funds for the Central Universities, South-Central University for Nationalities [CZQ21018]
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A convenient and efficient synthetic protocol for the preparation of pyrimidoquinazolinone was established through Pd(II)-catalyzed carbonylative cyclization of N-aryl-2-aminopyrimidines with Mo(CO)(6) as carbon monoxide source. A series of 6H-pyrimido[2,1-b]quinazolin-6-one derivatives were obtained in good yields, and scale-up synthesis was investigated in this study.
A convenient and efficient synthetic protocol for the preparation of pyrimidoquinazolinone through Pd(II)-catalyzed carbonylative cyclization of N-aryl-2-aminopyrimidines with Mo(CO)(6) as carbon monoxide source is established. A series of 6H-pyrimido[2,1-b]quinazolin-6-one derivatives were obtained in good yields. The scale-up synthesis was investigated.
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