Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue 7, Pages 1795-1800Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202100317
Keywords
aza-heterocycles; biomass; catalysis; copper; multi-C-1 synthon
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Funding
- DST-FIST (fund for the improvement of S&T infrastructure) [SR/FST/CST266/2015(c)]
- Ministry of Science and Technology, Taiwan [MOST 109-2113-M-037 -013]
- SRM Institute of Science and Technology
- TEEP@AsiaPlus from the Ministry of Education (Taiwan)
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A copper-catalyzed oxidative coupling strategy has been developed for the synthesis of 4(3H)-quinazolinones and benzoimidazoquinazoline using glucose as a renewable C-1 synthon. Isotope labelling studies confirmed the role of glucose as a C-1 source, with significant features including the utilization of glucose as a multi-C-1 synthon, biomass-derived platform chemical as a carbon synthon, atom-economical conditions, and the synthesis of naturally occurring alkaloid and precursor.
A copper-catalyzed oxidative coupling strategy has been developed for the synthesis of 4(3H)-quinazolinones and benzoimidazoquinazoline using glucose as renewable C-1 synthon. Isotope labelling studies using C-13(6) D-glucose and DMSO-d(6) confirmed the role of D-glucose as C-1 source. The significant features of this method include (i) utilization of 0.25 to 0.5 equiv., of D-glucose as a multi-C-1 synthon; (ii) biomass-derived platform chemical as carbon synthon; (iii) atom-economical and benign conditions and; (iv) synthesis of naturally occurring alkaloid and precursor.
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