Anabaenopeptins: What We Know So Far

Cyanobacteria are microorganisms with photosynthetic mechanisms capable of colonizing several distinct environments worldwide. They can produce a vast spectrum of bioactive compounds with different properties, resulting in an improved adaptative capacity. Their richness in secondary metabolites is related to their unique and diverse metabolic apparatus, such as Non-Ribosomal Peptide Synthetases (NRPSs). One important class of peptides produced by the non-ribosomal pathway is anabaenopeptins. These cyclic hexapeptides demonstrated inhibitory activity towards phosphatases and proteases, which could be related to their toxicity and adaptiveness against zooplankters and crustaceans. Thus, this review aims to identify key features related to anabaenopeptins, including the diversity of their structure, occurrence, the biosynthetic steps for their production, ecological roles, and biotechnological applications.

Automated summary

Cyanobacteria are microorganisms with diverse secondary metabolites, including an important class of peptides called anabaenopeptins which possess inhibitory activity and may be toxic and adaptive to certain aquatic organisms. This review aims to explore key features related to anabaenopeptins, such as their structural diversity, occurrence, biosynthetic steps, ecological roles, and biotechnological applications.