4.6 Article

Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome

Related references

Note: Only part of the references are listed.
Review Cardiac & Cardiovascular Systems

Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Serena Zacchigna et al.

Summary: Echocardiography is a reliable method for assessing cardiac function in small animals, but lacks standardization in measurement procedures. This paper provides guidance on the appropriate acquisition and analysis of echocardiographic parameters in small animals.

CARDIOVASCULAR RESEARCH (2021)

Review Cardiac & Cardiovascular Systems

Non-coding RNA therapeutics for cardiac regeneration

Luca Braga et al.

Summary: Non-coding RNAs play crucial roles in regulating cardiac regeneration after myocardial infarction, with certain miRNAs stimulating cardiomyocyte proliferation while others suppressing it. This information has significant therapeutic implications for promoting cardiac regeneration.

CARDIOVASCULAR RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction

Andrew R. Kompa et al.

Summary: Subcutaneous implantation of TheraCyte devices containing the secretome of human cardiac stem cells attenuated adverse cardiac remodelling and preserved cardiac function following myocardial infarction. The secretome-based therapy led to reduced fibrosis, increased myocardial vascular density, and improved cardiac function.

CARDIOVASCULAR RESEARCH (2021)

Article Cell Biology

Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype

Yiteng Liao et al.

Summary: miR-146b-5p is a hypoxia-induced regulator that governs the pro-fibrotic phenotype transition of cardiac cells. Local inhibition of miR-146b-5p may represent a novel therapeutic approach to treat cardiac fibrotic remodeling and dysfunction following MI.

PROTEIN & CELL (2021)

Article Cell & Tissue Engineering

Brachyury engineers cardiac repair competent stem cells

Mark Li et al.

Summary: By introducing early cardiogenic genes, engineered cardiac repair competent stem cells with antioxidant, vasculogenic, and immunomodulatory traits have been successfully developed. These stem cells have important application value in treating heart diseases such as ischemic heart failure.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair

Chloe Pezzana et al.

Summary: EVs play a crucial role in the paracrine effects of stem cells, but face challenges in delivery such as fast wash-out and whole-body distribution limits. Researchers are exploring different administration routes to enhance the residence time and targeting of EVs in the target tissue.

TRENDS IN MOLECULAR MEDICINE (2021)

Article Cell & Tissue Engineering

Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome

D. Kent Arrell et al.

Summary: Stem cell paracrine activity, specifically secreted proteins by cardiopoietic cells, play a key role in cardiac repair. Through systems analytics and RNA sequencing, miR-146 was identified as a regulator upstream of the decoded secretome. The therapeutic impact of cardiopoietic cell therapy on infarcted hearts is influenced by the inherent vasculogenic properties and smooth muscle differentiation of the secreted proteins.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Article Cell & Tissue Engineering

Brief Report: Ventricular Remodeling in Ischemic Heart Failure Stratifies Responders to Stem Cell Therapy

Satsuki Yamada et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

Review Biotechnology & Applied Microbiology

MicroRNA Mediated Cardioprotection - Is There a Path to Clinical Translation?

Timo Z. Nazari-Shafti et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Cell & Tissue Engineering

Exosomes: Beyond stem cells for cardiac protection and repair

Carolina Balbi et al.

STEM CELLS (2020)

Article Cell & Tissue Engineering

Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome

D. Kent Arrell et al.

NPJ REGENERATIVE MEDICINE (2020)

Article Cell & Tissue Engineering

Extracellular Vesicles Released by Allogeneic Human Cardiac Stem/Progenitor Cells as Part of Their Therapeutic Benefit

Hocine Rachid Hocine et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

Editorial Material Cardiac & Cardiovascular Systems

Clinical Experience With Regenerative Therapy in Heart Failure Advancing Care With Cardiopoietic Stem Cell Interventions

Jozef Bartunek et al.

CIRCULATION RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Cell therapy trials for heart regeneration - lessons learned and future directions

Philippe Menasche

NATURE REVIEWS CARDIOLOGY (2018)

Article Engineering, Biomedical

A mechanistic roadmap for the clinical application of cardiac cell therapies

Eduardo Marban

NATURE BIOMEDICAL ENGINEERING (2018)

Article Cardiac & Cardiovascular Systems

Global position paper on cardiovascular regenerative medicine

Francisco Fernandez-Aviles et al.

EUROPEAN HEART JOURNAL (2017)

Review Cell Biology

MiR-146a/b: a family with shared seeds and different roots

Mark R. Paterson et al.

PHYSIOLOGICAL GENOMICS (2017)

Article Cardiac & Cardiovascular Systems

Stem cell therapy for heart failure: Ensuring regenerative proficiency

Andre Terzic et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2016)

Article Medicine, Research & Experimental

Cardiopoietic index predicts heart repair fitness of patient-derived stem cells

Ruben Crespo-Diaz et al.

BIOMARKERS IN MEDICINE (2015)

Article Cardiac & Cardiovascular Systems

Cardiopoietic Stem Cell Therapy in Heart Failure

Jozef Bartunek et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

Article Biochemical Research Methods

Topological analysis and interactive visualization of biological networks and protein structures

Nadezhda T. Doncheva et al.

NATURE PROTOCOLS (2012)

Review Cardiac & Cardiovascular Systems

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart

Maria Mirotsou et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Guided Cardiopoiesis Enhances Therapeutic Benefit of Bone Marrow Human Mesenchymal Stem Cells in Chronic Myocardial Infarction

Atta Behfar et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)