Journal
ACTA TROPICA
Volume 148, Issue -, Pages 1-7Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.actatropica.2015.04.007
Keywords
Malaria; Plasmodium falciparum; Artemisinin resistance; Genomics; Molecular markers
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Funding
- Grants-in-Aid for Scientific Research [25870525] Funding Source: KAKEN
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Plasmodium falciparum, the malignant malaria parasite, has developed resistance to artemisinin, the most important and widely used antimalarial drug at present. Currently confined to Southeast Asia, the spread of resistant parasites to Africa would constitute a public health catastrophe. In this review we highlight the recent contributions of genomics to our understanding how the parasite develops resistance to artemisinin and its derivatives, and how resistant parasites may be monitored and tracked in real-time, using molecular approaches. (C) 2015 Elsevier B.V. All rights reserved.
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