Related references
Note: Only part of the references are listed.USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy
Xibao Zhao et al.
AUTOPHAGY (2022)
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
Hong Sun et al.
CELL REPORTS (2021)
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Tuo Li et al.
SCIENCE (2021)
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Katherine R. Balka et al.
CELL REPORTS (2020)
Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
Li Zhong et al.
CELL DISCOVERY (2020)
Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice
Juli Bai et al.
COMMUNICATIONS BIOLOGY (2020)
Attenuation of cGAS/STING activity during mitosis
Brittany L. Uhlorn et al.
LIFE SCIENCE ALLIANCE (2020)
Structural basis for nucleosome-mediated inhibition of cGAS activity
Duanfang Cao et al.
CELL RESEARCH (2020)
The roles of histone variants in fine-tuning chromatin organization and function
Sara Martire et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
The molecular basis of tight nuclear tethering and inactivation of cGAS
Baoyu Zhao et al.
NATURE (2020)
Structural basis for sequestration and autoinhibition of cGAS by chromatin
Sebastian Michalski et al.
NATURE (2020)
Structural mechanism of cGAS inhibition by the nucleosome
Ganesh R. Pathare et al.
NATURE (2020)
BAF restricts cGAS on nuclear DNA to prevent innate immune activation
Baptiste Guey et al.
SCIENCE (2020)
Structural basis for the inhibition of cGAS by nucleosomes
Tomoya Kujirai et al.
SCIENCE (2020)
Structural basis of nucleosome-dependent cGAS inhibition
Joshua A. Boyer et al.
SCIENCE (2020)
Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)
Huawei Wang et al.
SCIENTIFIC REPORTS (2020)
cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing
Carolina Uggenti et al.
NATURE GENETICS (2020)
Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
Shufang Cui et al.
CELL REPORTS (2020)
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
Katherine C. Barnett et al.
CELL (2019)
Autophagic cell death restricts chromosomal instability during replicative crisis
Joe Nassour et al.
NATURE (2019)
cGAS in action: Expanding roles in immunity and inflammation
Andrea Ablasser et al.
SCIENCE (2019)
The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
Matteo Gentili et al.
CELL REPORTS (2019)
The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
Juli Bai et al.
DIABETES (2019)
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation
Wei Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?
Nelson O. Gekara et al.
SCIENCE SIGNALING (2019)
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
Christian Zierhut et al.
CELL (2019)
DNA sensing by the cGAS-STING pathway in health and disease
Mona Motwani et al.
NATURE REVIEWS GENETICS (2019)
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
Hui Jiang et al.
EMBO JOURNAL (2019)
cGAS and CD-NTase enzymes: structure, mechanism, and evolution
Philip J. Kranzusch
CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)
Tight nuclear tethering of cGAS is essential for preventing autoreactivity
Hannah E. Volkman et al.
ELIFE (2019)
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance
Wen Zhou et al.
CELL (2018)
Chromosomal instability drives metastasis through a cytosolic DNA response
Samuel F. Bakhoum et al.
NATURE (2018)
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
Mingjian Du et al.
SCIENCE (2018)
NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation
Xavier Lahaye et al.
CELL (2018)
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
Haipeng Liu et al.
NATURE (2018)
Chromatin and nucleosome dynamics in DNA damage and repair
Michael H. Hauer et al.
GENES & DEVELOPMENT (2017)
NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway
Run Fang et al.
JOURNAL OF IMMUNOLOGY (2017)
cGAS surveillance of micronuclei links genome instability to innate immunity
Karen J. Mackenzie et al.
NATURE (2017)
Mitotic progression following DNA damage enables pattern recognition within micronuclei
Shane M. Harding et al.
NATURE (2017)
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders
Liudmila Andreeva et al.
NATURE (2017)
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Selene Gluck et al.
NATURE CELL BIOLOGY (2017)
DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway
Juli Bai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
cGAS is essential for cellular senescence
Hui Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
cGAS is activated by DNA in a length-dependent manner
Stefanie Luecke et al.
EMBO REPORTS (2017)
Chromosome condensation and decondensation during mitosis
Wolfram Antonin et al.
CURRENT OPINION IN CELL BIOLOGY (2016)
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity (vol 17, pg 369, 2016)
Pengyan Xia et al.
NATURE IMMUNOLOGY (2016)
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
Qi Chen et al.
NATURE IMMUNOLOGY (2016)
ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
M. Raab et al.
SCIENCE (2016)
Mitochondrial DNA stress primes the antiviral innate immune response
A. Phillip West et al.
NATURE (2015)
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection
Megan H. Orzalli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1
Takayuki Abe et al.
JOURNAL OF VIROLOGY (2014)
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
Xiaomei Wu et al.
NUCLEIC ACIDS RESEARCH (2014)
A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis
Bryan J. Wilkins et al.
SCIENCE (2014)
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
Xu Zhang et al.
CELL REPORTS (2014)
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
Xin Li et al.
IMMUNITY (2013)
Structural mechanism of cytosolic DNA sensing by cGAS
Filiz Civril et al.
NATURE (2013)
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
Jiaxi Wu et al.
SCIENCE (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Lijun Sun et al.
SCIENCE (2013)
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
Karolin Luger et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells
M. Fenech et al.
MUTAGENESIS (2011)
Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations
Aniek Janssen et al.
SCIENCE (2011)
DNA-damage repair; the good, the bad, and the ugly
Razqallah Hakem
EMBO JOURNAL (2008)
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
Vassiliki Karantza-Wadsworth et al.
GENES & DEVELOPMENT (2007)
Autophagy suppresses tumor progression by limiting chromosomal instability
Robin Mathew et al.
GENES & DEVELOPMENT (2007)
A critical role for telomeres in suppressing and facilitating carcinogenesis
SE Artandi et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2000)
Share Paper
