4.7 Article

The Collagen Origin Influences the Degradation Kinetics of Guided Bone Regeneration Membranes

Journal

POLYMERS
Volume 13, Issue 17, Pages -

Publisher

MDPI
DOI: 10.3390/polym13173007

Keywords

bone regeneration; collagen membrane; hydrolytic degradation; collagen origin; bacterial collagenase; trypsin digestion; degradation testing; degradation kinetics

Funding

  1. Ministry of Economy and Competitiveness [PID2020-114694RB-100]
  2. European Regional Development Fund [PID2020-114694RB-100, A-BIO-157-UGR-18/FEDER]
  3. University of Granada/Regional Government of Andalusia Research Fund from Spain [A-BIO-157-UGR-18/FEDER]

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This study investigated the biodegradation pattern of five collagen membranes from different origins, with Evolution X-fine collagen membrane from porcine pericardium showing the highest resistance. On the other hand, Biocollagen and Parasorb Resodont from equine origin experienced the greatest degradation in certain challenge tests. Bacterial collagenase solution was found to be the most aggressive testing method.
Collagen membranes are currently the most widely used membranes for guided bone regeneration; however, their rapid degradation kinetics means that the barrier function may not remain for enough time to permit tissue regeneration to happen. The origin of collagen may have an important effect on the resistance to degradation. The aim of this study was to investigate the biodegradation pattern of five collagen membranes from different origins: Biocollagen, Heart, Evolution X-fine, CopiOs and Parasorb Resodont. Membranes samples were submitted to different degradation tests: (1) hydrolytic degradation in phosphate buffer saline solution, (2) bacterial collagenase from Clostridium histolyticum solution, and (3) enzyme resistance using a 0.25% porcine trypsin solution. Immersion periods from 1 up to 50 days were performed. At each time point, thickness and weight measurements were performed with a digital caliper and an analytic microbalance, respectively. ANOVA and Student-Newman-Keuls tests were used for comparisons (p < 0.05). Differences between time-points within the same membranes and solutions were assessed by pair-wise comparisons (p < 0.001). The Evolution X-fine collagen membrane from porcine pericardium attained the highest resistance to all of the degradation tests. Biocollagen and Parasorb Resodont, both from equine origin, experienced the greatest degradation when immersed in PBS, trypsin and C. histolyticum during challenge tests. The bacterial collagenase solution was shown to be the most aggressive testing method.

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