Journal
POLYMERS
Volume 13, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/polym13152569
Keywords
N-vinyl-2-pyrrolidone polymerization; polymerization mechanism; polymerization kinetics; doxorubicin
Categories
Funding
- Ministry of Science and Higher Education of the Russian Federation [075-15-2020-792, RF--190220X0031]
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Sulfanylethanoic and 3-sulfanylpropanoic acids were found to effectively regulate molecular weight and accelerate the radical polymerization of N-vinyl-2-pyrrolidone. Thiolate anions of mercapto acids were discovered to form a high-temperature redox initiating system with initiators during polymerization. Synthesized carboxyl-containing techelics of N-vinyl-2-pyrrolidone can slow down the release of anticancer drugs from aqueous solutions, showing potential application in pharmacology.
It was found that sulfanylethanoic and 3-sulfanylpropanoic acids are effective regulators of molecular weight with chain transfer constants of 0.441 and 0.317, respectively, and show an unexpected acceleration effect on the radical polymerization of N-vinyl-2-pyrrolidone, initiated by 2,2'-azobisisobutyronitrile. It was determined for the first time that the thiolate anions of mercapto acids form a high-temperature redox initiating system with 2,2'-azobisisobutyronitrile during the radical polymerization of N-vinyl-2-pyrrolidone in 1,4-dioxane. Considering the peculiarities of initiation, a kinetic model of the polymerization of N-vinyl-2-pyrrolidone is proposed, and it is shown that the theoretical orders of the reaction rate, with respect to the monomer, initiator, and chain transfer agent, are 1, 0.75, 0.25, and are close to their experimentally determined values. Carboxyl-containing techelics of N-vinyl-2-pyrrolidone were synthesized so that it can slow down the release of the anticancer drug, doxorubicin, from aqueous solutions, which can find its application in the pharmacological field.
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