Journal
PLOS PATHOGENS
Volume 17, Issue 8, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1009857
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Funding
- NIAID
- NIA of the NIH [AI153602, AG049042, R24AI120942]
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SARS-CoV-2 has a pathogenicity closer to SARS-CoV and MERS-CoV, and a transmissibility similar to common cold coronaviruses. The features of the receptor-binding domain and protease cleavage of the spike protein enable SARS-CoV-2 to become a pandemic virus.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS-CoV-2 to be a pandemic virus.
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