Journal
PLOS PATHOGENS
Volume 17, Issue 6, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1009445
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Funding
- Bill & Melinda Gates Foundation [OPP1100514]
- [NIH R01-043596]
- [R21-142656]
- Bill and Melinda Gates Foundation [OPP1100514] Funding Source: Bill and Melinda Gates Foundation
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The longitudinal study in an urban slum of Dhaka, Bangladesh, found that multiple Cryptosporidium infections in young children are associated with lower parasite burden, more sub-clinical infections, and the development of growth faltering.
We conducted a longitudinal study of cryptosporidiosis from birth to three years of age in an urban slum of Dhaka Bangladesh. Fecal DNA was extracted from monthly surveillance samples and diarrheal stool samples collected from 392 infants from birth to three years. A pan-Cryptosporidium qPCR assay was used to identify sub-clinical and symptomatic cryptosporidiosis. Anthropometric measurements were collected quarterly to assess child nutritional status. 31% (121/392) of children experienced a single and 57% (222/392) multiple infections with Cryptosporidium. Repeat infections had a lower burden of parasites in the stool (Cq slope = -1.85; p<0.0001) and were more likely to be sub-clinical (Chi square test for trend; p = 0.01). Repeat infections were associated with the development of growth faltering (Pearson correlation = -0.18; p = 0.0004). High levels of fecal IgA antibodies against the Cryptosporidium Cp23 sporozoite protein at one year of life were associated with a delay in reinfection and amelioration of growth faltering through three years of life (HAZ IgA high responders -1.323 +/- 0.932 versus HAZ -1.731 +/- 0.984 p = 0.0001). We concluded that non-sterile immunity to cryptosporidiosis in young children was associated with high levels of mucosal IgA anti-Cp23 and protection from diarrhea and growth faltering.
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