4.7 Article

Branched chain fatty acid synthesis drives tissue-specific innate immune response and infection dynamics of Staphylococcus aureus

Related references

Note: Only part of the references are listed.
Review Immunology

The Role of Macrophages in Staphylococcus aureus Infection

Grace R. Pidwill et al.

Summary: Staphylococcus aureus, a member of human commensal microflora, can cause serious diseases by circumventing the innate immune system and establishing infections. Professional phagocytes like macrophages and neutrophils play key roles in containing and resolving S. aureus infections, while the bacteria have evolved multiple strategies to survive, manipulate, and escape from macrophages. Understanding the interactions between macrophages and S. aureus may be beneficial for future therapeutic developments.

FRONTIERS IN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Staphylococcus aureus adapts to the host nutritional landscape to overcome tissue-specific branched-chain fatty acid requirement

Wei Ping Teoh et al.

Summary: During infection, pathogenic microbes such as Staphylococcus aureus adapt to the host's nutritional environment by scavenging necessary nutrients, including lipoic acid, and enzymes required for metabolism. The ability to acquire lipoic acid and unsaturated fatty acids from the host environment is crucial for the pathogen's virulence in different infection sites. The findings emphasize the importance of host lipid assimilation for bacterial survival and suggest challenges in targeting bacterial lipogenesis as an antibacterial strategy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat

Kengo Kitadokoro et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

Bacterial lipolysis of immune-activating ligands promotes evasion of innate defenses

Xi Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Pharmacology & Pharmacy

Keep recycling going: New approaches to reduce LDL-C

Andres J. P. Klein-Szanto et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Acyl-chain selectivity and physiological roles of Staphylococcus aureus fatty acid-binding proteins

Maxime G. Cuypers et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Microbiology

Staphylococcal (phospho)lipases promote biofilm formation and host cell invasion

Minh-Thu Nguyenae et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2018)

Article Microbiology

Redirection of Metabolism in Response to Fatty Acid Kinase in Staphylococcus aureus

Zachary DeMars et al.

JOURNAL OF BACTERIOLOGY (2018)

Article Microbiology

Staphylococcus aureus Utilizes Host-Derived Lipoprotein Particles as Sources of Fatty Acids

Phillip C. Delekta et al.

JOURNAL OF BACTERIOLOGY (2018)

Article Microbiology

VfrB Is a Key Activator of the Staphylococcus aureus SaeRS Two-Component System

Christina N. Krute et al.

JOURNAL OF BACTERIOLOGY (2017)

Article Multidisciplinary Sciences

Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

Minh-Thu Nguyen et al.

NATURE COMMUNICATIONS (2017)

Review Immunology

Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus

Fermin E. Guerra et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

Review Biochemistry & Molecular Biology

The Staphylococcus aureus FASII bypass escape route from FASII inhibitors

Claire Morvan et al.

BIOCHIMIE (2017)

Article Microbiology

Clinical Relevance of Type II Fatty Acid Synthesis Bypass in Staphylococcus aureus

Karine Gloux et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

Article Biochemistry & Molecular Biology

Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family

Tyler C. Broussard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Microbiology

Synthesis and function of phospholipids in Staphylococcus aureus

Sebastian Kuhn et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2015)

Review Peripheral Vascular Disease

Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism

Junji Kobayashi et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2015)

Review Biochemistry & Molecular Biology

How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics

Jiangwei Yao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

A Sensitive and Robust Enzyme Kinetic Experiment Using Microplates and Fluorogenic Ester Substrates

R. Jeremy Johnson et al.

JOURNAL OF CHEMICAL EDUCATION (2015)

Review Biochemistry & Molecular Biology

Intestinal lipid absorption and lipoprotein formation

M. Mahmood Hussain

CURRENT OPINION IN LIPIDOLOGY (2014)

Article Multidisciplinary Sciences

Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

Joshua B. Parsons et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biochemistry & Molecular Biology

Bacterial lipids: Metabolism and membrane homeostasis

Joshua B. Parsons et al.

PROGRESS IN LIPID RESEARCH (2013)

Article Hematology

Intracellular Trafficking and Secretion of VLDL

Samata Tiwari et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Lipoproteins, cholesterol homeostasis and cardiac health

Tyler F. Daniels et al.

International Journal of Biological Sciences (2012)

Review Immunology

Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity

James E. Cassat et al.

SEMINARS IN IMMUNOPATHOLOGY (2012)

Article Biochemistry & Molecular Biology

Structural evidence of α-aminoacylated lipoproteins of Staphylococcus aureus

Miwako Asanuma et al.

FEBS JOURNAL (2011)

Article Multidisciplinary Sciences

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

Joshua B. Parsons et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Not Just Fat: The Structure and Function of the Lipid Droplet

Toyoshi Fujimoto et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Characterization of N-terminal Structure of TLR2-activating Lipoprotein in Staphylococcus aureus

Kazuki Tawaratsumida et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways

Ira J. Goldberg et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Multidisciplinary Sciences

Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins

Juliane Bubeck Wardenburg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Education, Scientific Disciplines

Understanding lipoproteins as transporters of cholesterol and other lipids

KD Biggerstaff et al.

ADVANCES IN PHYSIOLOGY EDUCATION (2004)

Review Biochemistry & Molecular Biology

Forty years of bacterial fatty acid synthesis

CO Rock et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)