The association between tropical cyclones and dengue fever in the Pearl River Delta, China during 2013-2018: A time-stratified case-crossover study Tropical cyclones and dengue fever

BackgroundStudies have shown that tropical cyclones are associated with several infectious diseases, while very few evidence has demonstrated the relationship between tropical cyclones and dengue fever. This study aimed to examine the potential impact of tropical cyclones on dengue fever incidence in the Pearl River Delta, China. MethodsData on daily dengue fever incidence, occurrence of tropical cyclones and meteorological factors were collected between June and October, 2013-2018 from nine cities in the Pearl River Delta. Multicollinearity of meteorological variables was examined via Spearman correlation, variables with strong correlation (r>0.7) were not included in the model simultaneously. A time-stratified case-crossover design combined with conditional Poisson regression model was performed to evaluate the association between tropical cyclones and dengue fever incidence. Stratified analyses were performed by intensity grades of tropical cyclones (tropical storm and typhoon), sex (male and female) and age-groups (<18, 18-59, >= 60 years). ResultsDuring the study period, 20 tropical cyclones occurred and 47,784 dengue fever cases were reported. Tropical cyclones were associated with an increased risk of dengue fever in the Pearl River Delta region, with the largest relative risk of 1.62 with the 95% confidence interval (1.45-1.80) occurring on the lag 5 day. The strength of association was greater and lasted longer for typhoon than for tropical storm. There was no difference in effect estimates between males and females. However, individuals aged over 60 years were more vulnerable than others. ConclusionsTropical cyclones are associated with increased risk of local dengue fever incidence in south China, with the elderly more vulnerable than other population subgroups. Health protective strategies should be developed to reduce the potential risk of dengue epidemic after tropical cyclones. Author summaryDengue fever, a mosquito-borne tropical infectious disease, has been increasingly serious in recent decades, causing great healthcare burden in low-latitude regions and countries. Aedes is the vector of dengue fever, particularly sensitive to climatic conditions during all stages of the life cycle. Numerous epidemiological studies have demonstrated the association between dengue fever and meteorological factors (e.g., temperature, precipitation and relative humidity). Tropical cyclones are a common extreme weather events in the low latitude and have been associated with the outbreak of several infectious diseases. However, the impact of tropical cyclones on the incidence of dengue fever has not been well clarified. In this study, we explored the association between tropical cyclones and dengue fever in the Pearl River Delta region, China. The results showed that the local incidence of dengue fever was substantially associated with tropical cyclones over a certain lag period, with the effect estimate greater for stronger tropical cyclones. The elderly was more vulnerable than any other population subgroups. The findings highlighted the importance of developing public health surveillance, preparedness, and response targeting the outbreak of dengue fever during the tropical cyclone season.

Automated summary

This study found a significant association between tropical cyclones and local dengue fever incidence in the Pearl River Delta region of south China, with stronger effects observed for typhoons. Individuals over 60 years old were more vulnerable to the impact of tropical cyclones on dengue fever compared to other population subgroups. These findings emphasize the importance of developing public health strategies to address the increased risk of dengue fever outbreaks following tropical cyclones.