Journal
GENETICS AND MOLECULAR RESEARCH
Volume 15, Issue 2, Pages -Publisher
FUNPEC-EDITORA
DOI: 10.4238/gmr.15028289
Keywords
MicroRNA; Polymorphism; Gastric cancer; Review
Funding
- National Natural Science Foundation of China [81560429]
- Applied Basic Research Project of Yunnan Province [201501UH00069]
Ask authors/readers for more resources
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent. Sequence variants, such as single nucleotide polymorphisms (SNPs) in pri-miRNA, pre-miRNA, promoter regions, or miRNA-target sites, can influence miRNA function, thereby contributing to the pathological features of human disease. In this review, we focus on miRNA-related SNPs in gastric cancer and comprehensively analyze some commonly studied SNPs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
