An association of the MCP-1 and CCR2 gene polymorphisms with oral lichen planus

Objective. The purpose of this study was to investigate the frequency of monocyte chemoattractant protein (MCP)-1 CCR2 gene Study Design. A cohort of 50 patients with OLP and 142 control participants without OLP were recruited to investigate the frequency of MCP-1 and CCR2 gene polymorphisms. Chi-square and Fisher's exact tests were used. Student t test and analysis of variance were used to compare demographic data between groups. Results. The MCP AA genotype was less common in the patient group (52%) than in the control group (66.2%; odds ratio [OR] = 0.553; 95% confidence interval [CI], 0.287-1.065; P = .075). The MCP G allele was higher in the patient group (48%) than in the control group (33.8%; OR = 1.808; 95% CI, 0.939-3.479; P= .075). The frequency of the MCP GG genotype was observed to be higher in the patient group (4%) than in the controls (0.7%; OR: 5.875, 95% CI:0.521-66,24; p = 0.106). The CCR2 64I64I genotype was more common in the patient group (6%) than in the control group (2.8%). All results were not statistically significant. Conclusion. We suggest that the G allele of MCP-1 and 64I64I genotype of CCR2 polymorphisms do not pose an increased risk for 2021;132:708-714)

Automated summary

This study investigated the frequency of MCP-1 CCR2 gene polymorphisms in patients with OLP and control participants, finding differences in certain genotypes but no statistically significant results.