Journal
OPEN BIOLOGY
Volume 11, Issue 9, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.210228
Keywords
fatty acylation; palmitoylation; zDHHC enzymes; MBOATs; signal transduction
Categories
Funding
- NIH [RO1 GM116860]
- Commonwealth Foundation for Cancer Research
- Center for Experimental Therapeutics at Memorial Sloan Kettering Cancer Center
- National Institutes of Health to Memorial Sloan Kettering Cancer Center [P30 CA008748]
Ask authors/readers for more resources
Fatty acylation is a crucial protein modification that affects protein affinity, signaling pathways, and cellular functions. Research in this field offers new therapeutic opportunities for targeting human diseases.
Fatty acylation is a widespread form of protein modification that occurs on specific intracellular and secreted proteins. Beyond increasing hydrophobicity and the affinity of the modified protein for lipid bilayers, covalent attachment of a fatty acid exerts effects on protein localization, inter- and intramolecular interactions and signal transduction. As such, research into protein fatty acylation has been embraced by an extensive community of biologists. This special issue highlights advances at the forefront of the field, by focusing on two families of enzymes that catalyse post-translational protein fatty acylation, zDHHC palmitoyl acyltransferases and membrane-bound O-acyl transferases, and signalling pathways regulated by their fatty acylated protein substrates. The collected contributions catalogue the tremendous progress that has been made in enzyme and substrate identification. In addition, articles in this special issue provide insights into the pivotal functions of fatty acylated proteins in immune cell, insulin and EGF receptor-mediated signalling pathways. As selective inhibitors of protein fatty acyltransferases are generated, the future holds great promise for therapeutic targeting of fatty acyltransferases that play key roles in human disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available