Green Biosynthesis of Flaxseed Gold Nanoparticles (Au-NPs) as Potent Anti-cancer Agent Against Breast Cancer Cells

In recent research work aqueous extract of flaxseed (Linum usitatissimum) is used for synthesis of gold nanoparticles (Au-NPs). Synthesized NPs was characterized by various spectroscopic techniques such as FTIR, UV-visible absorption, HPLC, Powder-XRD, X-ray photoelectron spectroscopy XPS, EDX, and TEM analysis. The flaxseed mediated Au-NPs adopt spherical and triangular morphology and distributed without aggregation in the range of 3.4-6.9 nm. The antioxidant efficacy of Au-NPs evaluated by free radical scavenging DPPH assay showed comparable potentials with ABTS assay. Further the synthesized Au-NPs are investigated for their anti-tumor activity against hepatocellular carcinoma (HepG2), breast adenocarcinoma (MCF-7), and colon carcinoma (HCT-116) cell lines. Docking studies explored the eminent affinity of SDG against MCF-7 than lotaustralin, linamarin, linustatin, and neolinustatin glycosides. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

The aqueous extract of flaxseed is used for synthesizing gold nanoparticles in recent research, exhibiting potential antioxidant and anti-tumor activities against various cancer cell lines. Docking studies reveal significant affinity of certain components against specific cancer cell lines.