4.4 Article

Worsened Parkinson's Disease Progression: Impact of the COVID-19 Pandemic

Journal

JOURNAL OF PARKINSONS DISEASE
Volume 11, Issue 4, Pages 1579-1583

Publisher

IOS PRESS
DOI: 10.3233/JPD-212779

Keywords

Parkinson's disease; COVID-19; confinement; motor disease progression; MDS-UPDRS part III

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The study found that motor symptoms worsened and motor disease progression significantly increased in patients with Parkinson's disease during pandemic-related restrictions compared to before the COVID-19 outbreak.
Whilst some studies investigated the impact of viral infection or reduced access to medication during the COVID-19 pandemic in patients with Parkinson's disease (PD), data on the effects of pandemic restrictions are still scarce. We retrospectively analyzed motor symptoms of longitudinally followed PD patients (n = 264) and compared motor disease progression before and during the COVID-19 pandemic. Additionally, we performed a trend analysis of the yearly evolution of motor symptoms in 755 patients from 2016 until 2021. We observed a worsening of motor symptoms and a significantly increased motor disease progression during pandemic-related restrictions as compared to before the COVID-19 outbreak.

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