Journal
GENETICS
Volume 203, Issue 1, Pages 65-107Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.115.186221
Keywords
GCN4; translation elongation; translation initiation
Categories
Funding
- United Kingdom Biotechnology and Biological Sciences Research Council [BB/L000652/1, BB/L020157/1, BB/M006565/1]
- National Institutes of Health (NIH) [GM57483]
- Intramural Research Program of the NIH
- BBSRC [BB/M006565/1, BB/G012571/1, BB/N014049/1, BB/L020157/1, BB/H010599/1, BB/L000652/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L000652/1, BB/L020157/1, BB/G012571/1, BB/H010599/1, BB/M006565/1, BB/N014049/1] Funding Source: researchfish
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In this review, we provide an overview of protein synthesis in the yeast Saccharomyces cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other eukaryotes, and molecular genetic studies in budding yeast have provided critical insights into the fundamental process of translation as well as its regulation. The review focuses on the initiation and elongation phases of protein synthesis with descriptions of the roles of translation initiation and elongation factors that assist the ribosome in binding the messenger RNA (mRNA), selecting the start codon, and synthesizing the polypeptide. We also examine mechanisms of translational control highlighting the mRNA cap-binding proteins and the regulation of GCN4 and CPA1 mRNAs.
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