Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 18, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijerph18126409
Keywords
breast cancer; family history; epidemiology; genetic predisposition; environment
Funding
- Hallym University Research Fund [HURF-202003]
- National Research Foundation (NRF) of Korea [NRF-2018R1D1A1A0-2085328, NRF-2019-R1G1A1004679]
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This study utilized data from the Korean Genome and Epidemiology Study (KoGES) to investigate the relationship between breast cancer development and a family history of breast cancer in Korea. The results showed that a family history of breast cancer is a significant risk factor for breast cancer in Korea, especially for premenopausal women with a maternal history of breast cancer. Intensive screening and risk-reducing strategies should be considered for this vulnerable subpopulation.
Background: Breast cancer is the most common cancer among women. The Korean Genome and Epidemiology Study (KoGES) is a large cohort study that is available to the public. Using this large cohort study, we aimed to unravel the relationship between breast cancer development and a family history of breast cancer in Korea. Methods: This cohort study relied on data from the KoGES from 2001 through 2013. A total of 211,725 participants were screened. Of these, 129,374 women were evaluated. They were divided into two groups, including participants with and without breast cancer. A logistic regression model was used to retrospectively analyze the odds ratio of breast cancer history in families of women with and without breast cancer. Results: Of 129,374 women, 981 had breast cancer. The breast cancer group had more mothers and siblings with histories of breast cancer (p < 0.001). A history of breast cancer in the participant's mother resulted in an odds ratio of 3.12 (1.75-5.59), and a history of breast cancer in the participant's sibling resulted in an odds ratio of 2.63 (1.85-3.74). There was no interaction between the history of maternal breast cancer and the history of sibling breast cancer. Based on the subgroup analysis, family history was a stronger factor in premenopausal women than in menopausal and postmenopausal women. Conclusions: A family history of breast cancer is a significant risk factor for breast cancer in Korea. Premenopausal women with a maternal history of breast cancer are of particular concern. Intensive screening and risk-reducing strategies should be considered for this vulnerable subpopulation.
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