Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 18, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijerph18147239
Keywords
first-episode psychosis; early intervention; treatment; outcome; randomised controlled trial
Funding
- Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (ISCIII)
- European Regional Development Fund (ERDF) [PI10/01430, PI15/00789, PI18/0155, PI19/00569]
Ask authors/readers for more resources
The study found that using cognitive behavioral therapy as an adjunctive treatment can improve functioning, reduce depressive, negative, and general psychotic symptoms, and enhance treatment adherence for first-episode psychosis patients. This integrated treatment approach may help improve clinical and functional outcomes for first-episode psychosis.
Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The aim of this study was to compare the efficacy of a combined clinical treatment involving Cognitive Behavioural Therapy (CBT) as an adjunctive to treatment-as-usual (TAU) (CBT+TAU) versus TAU alone for FEP. Patients and methods: In this multicentre, single-blind, randomised controlled trial, 177 participants were randomly allocated to either CBT+TAU or TAU. The primary outcome was post-treatment patient functioning. Results: The CBT+TAU group showed a greater improvement in functioning, which was measured using the Global Assessment Functioning (GAF) and Functioning Assessment Short Test (FAST), compared to the TAU group post-treatment. The CBT+TAU participants exhibited a greater decline in depressive, negative, and general psychotic symptoms; a better awareness of the disease and treatment adherence; and a greater increase in brain-derived neurotrophic factor levels than TAU participants. Conclusions: Early intervention based on a combined clinical treatment involving CBT as an adjunctive to standard treatment may improve clinical and functional outcomes in FEP.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available