Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2021.697621
Keywords
aging; animal models; inbred C57BL mice; behavior rating scale; spatial memory; locomotion; anxiety; handgrip strength
Categories
Funding
- JSPS KAKENHI [24730642, 25560382, 26115532, 26430076, 25293331, 15H03103, 18K07460, 19K22834, 19H04044, 21K19752]
- Naito Foundation
- Japan Foundation for Aging
- Grants-in-Aid for Scientific Research [19K22834, 19H04044, 21K19752, 18K07460, 15H03103, 24730642, 25560382, 26115532, 25293331, 26430076] Funding Source: KAKEN
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The study found that mice exhibit significant functional changes at different ages, with physical function declining from 6 months and cognitive function deteriorating later. Each behavioral trait has a unique pattern of aging, and anxiety-like behaviors increase with age.
Aging is characterized generally by progressive and overall physiological decline of functions and is observed in all animals. A long line of evidence has established the laboratory mouse as the prime model of human aging. However, relatively little is known about the detailed behavioral and functional changes that occur across their lifespan, and how this maps onto the phenotype of human aging. To better understand age-related changes across the life-span, we characterized functional aging in male C57BL/6J mice of five different ages (3, 6, 12, 18, and 22 months of age) using a multi-domain behavioral test battery. Spatial memory and physical activities, including locomotor activity, gait velocity, and grip strength progressively declined with increasing age, although at different rates; anxiety-like behaviors increased with aging. Estimated age-related patterns showed that these functional alterations across ages are non-linear, and the patterns are unique for each behavioral trait. Physical function progressively declines, starting as early as 6 months of age in mice, while cognitive function begins to decline later, with considerable impairment present at 22 months of age. Importantly, functional aging of male C57BL/6J mouse starts at younger relative ages compared to when it starts in humans. Our study suggests that human-equivalent ages of mouse might be better determined on the basis of its functional capabilities.
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