B cells promote CD8 T cell primary and memory responses to subunit vaccines

The relationship between B cells and CD4 T cells has been carefully studied, revealing a collaborative effort in which B cells promote the activation, differentiation, and expansion of CD4 T cells while the so-called helper cells provide signals to B cells, influencing their class switching and fate. Interactions between B cells and CD8 T cells are not as well studied, although CD8 T cells exhibit an accelerated contraction after certain infections in B-cell-deficient mice. Here, we find that B cells significantly enhance primary CD8 T cell responses after vaccination. Moreover, memory CD8 numbers and function are impaired in B-cell-deficient animals, leading to increased susceptibility to bacterial challenge. We also show that interleukin-27 production by B cells contributes to their impact on primary, but not memory, CD8 responses. Better understanding of the interactions between CD8 T cells and B cells may aid in the design of more effective future vaccine strategies.

Automated summary

The relationship between B cells and CD4 T cells is a collaborative one, with B cells promoting the activation and expansion of CD4 T cells, while CD4 T cells can influence the class switching and fate of B cells. Although interactions between B cells and CD8 T cells are not well studied, B cells have a significant impact on primary CD8 T cell responses, as demonstrated after vaccination.