Complex multimorbidity and mortality in Japan: a prospective propensity-matched cohort study

Objectives There are limitations to defining multimorbidity (MM) based on a simple count of diseases. To address these limitations, the concept of complex MM (CMM) focuses on how many body systems are affected in a single patient, rather than counting comorbid conditions. This study compared the prediction of mortality among older Japanese adults between CMM and conventional MM. Design A population-based prospective cohort study. Setting The Japan Gerontological Evaluation Study, a nationwide longitudinal cohort study, which ran from 2010 to 2016. Participants Functionally independent individuals who were older than 65 and had complete illness data at the time of baseline survey were eligible. Outcomes measure CMM was defined as the coexistence of 3 or more body system disorders at baseline. We calculated the propensity for each individual to develop CMM based on a wide array of characteristics, including socioeconomic status and health behaviours. Individuals with and without CMM were then matched on their propensity scores before we estimated overall survival using a log-rank test. Results Our 6-year follow-up included 38 889 older adults: 20 233 (52.0%) and 7565 (19.5%) adults with MM and CMM, respectively. In the MM-matched cohort (n=15 666 pairs), the presence of MM was significantly associated with increased mortality (HR 1.07; 95% CI 1.01 to 1.14; p=0.02 by the log-rank test). A similar mortality association was found in the CMM-matched cohort (n=7524 pairs, HR, 1.07; 95% CI 0.99 to 1.16; p=0.08 by the log-rank test). Conclusion This is the first study to report the association between CMM and mortality among older adults in Japan. MM and CMM predict mortality in older adults to a similar degree. This finding needs to be replicated with more precision in larger samples.

Automated summary

This study compared the prediction of mortality among older Japanese adults between complex multimorbidity (CMM) and conventional multimorbidity (MM), finding that both CMM and MM similarly predict mortality in older adults. Further replication studies with larger samples are needed to confirm these findings.