Journal
GENES TO CELLS
Volume 21, Issue 4, Pages 350-357Publisher
WILEY-BLACKWELL
DOI: 10.1111/gtc.12345
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Funding
- Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program
- JSPS KAKENHI [15K06978, 25860020]
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [25860020, 16K18866, 26840014, 15K06978] Funding Source: KAKEN
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Tyrosine kinases are key enzymes that play critical roles in growth signaling, the abnormal activation of which is associated with various human cancers. Activation of tyrosine kinases is mediated by tyrosine phosphorylation in the activation-loop, which transforms the catalytic domain to the active state conformation. Cancer mutations are supposed to transform the conformation of the catalytic domain into the active-form independent of the phosphorylation state of the activation-loop. Here, we report structural and biophysical analyses of cancer mutations of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FGFR1). Based on the nuclear magnetic resonance analyses, phosphorylation of the activation-loop exhibited cooperative structural transition in the activation-loop, C-helix and P-loop regions, whereas cancer mutations induced structural transformation at either one or two of these regions.
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