Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 13, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202100041
Keywords
artificial muscles; carbon nanotubes; dielectric elastomer actuators; foreign body response; graphene
Funding
- Australian Research Council (ARC) [CE140100012]
- Australian National Fabrication Facility (ANFF) Materials Node
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The inability to replace human muscle in surgical practice is a significant challenge. An artificial muscle controlled by the nervous system is considered a potential solution for this, even though mechanical, electrical, and biological issues have prevented clinical application to date. Progress may be made in the near future by improving the actuation properties of the elastomer, integrating seamlessly or wirelessly between the nervous system and the artificial muscle, and reducing the foreign body response.
The inability to replace human muscle in surgical practice is a significant challenge. An artificial muscle controlled by the nervous system is considered a potential solution for this. Here, this is defined as a neuromuscular prosthesis. Muscle loss and dysfunction related to musculoskeletal oncological impairments, neuromuscular diseases, trauma or spinal cord injuries can be treated through artificial muscle implantation. At present, the use of dielectric elastomer actuators working as capacitors appears a promising option. Acrylic or silicone elastomers with carbon nanotubes functioning as the electrode achieve mechanical performances similar to human muscle in vitro. However, mechanical, electrical, and biological issues have prevented clinical application to date. Here materials and mechatronic solutions are presented which can tackle current clinical problems associated with implanting an artificial muscle controlled by the nervous system. Progress depends on the improvement of the actuation properties of the elastomer, seamless or wireless integration between the nervous system and the artificial muscle, and on reducing the foreign body response. It is believed that by combining the mechanical, electrical, and biological solutions proposed here, an artificial neuromuscular prosthesis may be a reality in surgical practice in the near future.
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