Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 19, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202100801
Keywords
intranasal administration; magnetic actuation; microrobots; stem cell delivery; superparamagnetic iron oxide nanoparticles
Funding
- National Research Foundation of Korea (NRF)
- DGIST R&D Program - Ministry of Science and ICT [2017K1A1A2013237, 2018M3C7A1056275, 21-CoE-BT-02]
- Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare [HI14C3228]
- National Research Foundation of Korea [21-COE-BT-02, 5120201213805] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Targeted stem cell delivery using magnetically powered microrobots through intranasal administration shows promise in treating central nervous system disorders in a minimally invasive manner.
Targeted stem cell delivery with microrobots has emerged as a potential alternative therapeutic strategy in regenerative medicine, and intranasal administration is an effective approach for minimally invasive delivery of therapeutic agents into the brain. In this study, a magnetically powered stem cell-based microrobot (Cellbot) is used for minimally invasive targeted stem cell delivery to the brain through the intranasal passage. The Cellbot is developed by internalizing superparamagnetic iron oxide nanoparticles (SPIONs) into human nasal turbinate stem cells. The SPIONs have no influence on hNTSC characteristics, including morphology, cell viability, and neuronal differentiation. The Cellbots are capable of proliferation and differentiation into neurons, neural precursor cells, and neurogliocytes. The Cellbots in the microfluidic channel can be reliably manipulated by an external magnetic field for orientation and position control. Using an ex vivo model based on brain organoids, it is determined that the Cellbots can be transplanted into brain tissue. Using a murine model, it is demonstrated that the Cellbots can be intranasally administered and magnetically guided to the target tissue in vivo. This approach has the potential to effectively treat central nervous system disorders in a minimally invasive manner.
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