Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 18, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202100716
Keywords
antibacteria; cascaded catalytic systems; diabetic wound healing; metal-organic frameworks; nanoreactors
Funding
- National Natural Science Foundation of China [82071750, 81772713, 81472411]
- Taishan Scholar Program of Shandong Province [tsqn20161077]
- Major Science and technology innovation project of Shandong Province [2019JZZY021002]
- Key projects of Qingdao Science and Technology Program [18-6-1-64-nsh]
- Research and Development Program of Shandong Province [2018GSF118197]
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By designing metal-organic framework-based nanoreactors loaded with glucose oxidase and peroxidase-like bovine hemoglobin, an effective cascaded catalytic antibacterial system has been constructed. This system can both starve and kill multidrug-resistant bacteria, and accelerate diabetic wound healing.
The application of the antibiotic drug has dramatically decreased the infection and promoted the development of surgery, but drug-resistant bacteria appeared along with the abuse of antibiotics. Especially, wound in diabetic patients provides more glucose for bacteria resulting in poor wound healing. Therefore, it is imminent to explore advanced agents for combating multidrug-resistant bacteria and accelerating diabetic wound healing. Herein, metal-organic frameworks based nanoreactors loaded with glucose oxidase (GOx) and peroxidase-like bovine hemoglobin (BHb) are designed to construct an effective cascaded catalytic antibacterial system. Therein, GOx can cost the glucose, and release H2O2 simultaneously, which can then be transformed into hydroxyl radicals by BHb. As a result, the as-prepared nanoreactors can play the roles of both starving and killing toward the multidrug-resistant bacteria. Furthermore, the produced gluconic acid can reduce the pH of working condition, which is beneficial for both the enhancement of peroxidase activity and the inhibition of the bacteria growth. More importantly, the constructed nanoreactors can be degraded and excreted from the body in the form of feces, which render the as-proposed nanoreactors qualified as effective and safe materials for both combating multidrug-resistant bacteria in vitro and accelerating the diabetic wound healing in vivo of the mouse model.
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