Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 20, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202100987
Keywords
biocompatible coordination polymers; contrast agents; magnetic resonance imaging; manganese compounds with water coordination; nanoparticles; Prussian blue; relaxivity
Funding
- Ohio Research Scholars Program
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The development of oral magnetic resonance imaging (MRI) contrast agents based on Gd3+-complexes is challenging due to the lack of acid and temporal stability. However, biocompatible NPs of the manganese Prussian blue analog show great potential in providing a solution with high stability and low toxicity.
The lack of acid stability in the stomach and of temporal stability when moving through the gastrointestinal (GI) tract has made the development of oral magnetic resonance imaging (MRI) contrast agents based on the platform of Gd3+-complexes problematic.On the other hand, the negative contrast enhancement produced by the T-2-weighted magnetic metal oxide nanoparticles (NPs) often renders the image readout difficult. Biocompatible NPs of the manganese Prussian blue analog K2Mn3[Fe-II(CN)(6)](2) exhibit extremely high stability under the acidic conditions of the gastric juice. Additionally, the high r(1) relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T-1-weighted oral contrast agent for MRI of the entire GI tract.
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