Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 20, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202101003
Keywords
excited-state energy; in vivo imaging; molecular engineering; NIR-II fluorophores; phototheranostics
Funding
- National Natural Science Foundation of China [22022404, 22074050, 21625503]
- Wuhan Scientific and Technological Projects [2019020701011441]
- Open Project Program of Fujian Key Laboratory of Functional Marine Sensing Materials China [MJUKF-FMSM202003]
- Open Fund of Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications [2020A01]
- Open Project Program of Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University [GKLBCN-20190105-01]
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This study successfully developed CCNU-1060 nanoparticles with NIR-II fluorescence-guided phototherapeutic properties using a molecular design strategy. This approach enabled high-spatial vessel imaging and effective tumor ablation.
Small organic phototherapeutic molecules of the second near-infrared (NIR-II) window (1000-1700 nm) serve as promising candidates for theranostics. However, developing such versatile agents for fluorescence-guided photodynamic/photothermal therapy remains a demanding task stirred by competitive energy dissipation pathways, including radiative decay, internal conversion, and intersystem crossing. To the best of current knowledge, the current paradigm for addressing the issue has deliberately approached the optimum balance among three deactivation processes through offsetting from each other, possibly leading to a comprehensively compromised theranostic efficacy. Few reports aim to modulate the three deactivation pathways excluding sacrificing any one of them. Herein, a molecular design strategy to construct a phototherapeutic organic fluorophore CCNU-1060, armed with NIR-II luorescence-guided phototherapeutic properties, is rationally developed. With a flexible motor, tetraphenylethene, bridged to the rigidified coplanar core boron-azadipyrromethene, the desired CCNU-1060 is subsequently encapsulated into an amphiphilic matrix to form CCNU-1060 nanoparticles (NPs), which match or transcend its precursor NJ-1060 NPs in the three energy dissipation processes. CCNU-1060 NPs are utilized to realize high-spatial vessel imaging and effective NIR-II fluorescence-guided phototherapeutic tumor ablation. This study unlocks a viewpoint of molecular engineering that simultaneously regulates multiple energy dissipation pathways for the construction of versatile phototherapy agents.
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