Journal
GENES AND IMMUNITY
Volume 17, Issue 4, Pages 220-227Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gene.2016.13
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Funding
- Chinese Ministry of Science and Technology [2012AA02A305, 2012ZX09103301, 2011ZX09401005]
- Chinese Ministry of Education [2012CB910700]
- Chinese Natural Science Foundation [81171955]
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Two heterodimeric receptors consisting of interleukin (IL)-20R2 are shared by three of the IL-20 family of cytokines, IL-19, IL-20 and IL-24. Along with IL-22, these cytokines are downstream effectors of IL-23 and have been implicated in keratinocyte functions and the pathogenesis of psoriasis. Surprisingly, whereas knocking out either the IL-23 or IL-22 gene abolished imiquimod-induced psoriatic phenotypes in mice, similar attempt for IL-20R2 had little effect. Here, we report that the apparent disparity may result from a new IL-20R2 isoform encoded by an alternatively spliced transcript which survived the previous attempt for IL-20R2 gene knockout via the exon I deletion.
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