Related references
Note: Only part of the references are listed.Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning
Tamara Zorbaz et al.
ACS CHEMICAL NEUROSCIENCE (2020)
Rational design, synthesis, and evaluation of uncharged, ?smart? bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase
Lukas Gorecki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases
Nikolina Macek Hrvat et al.
TOXICOLOGY LETTERS (2020)
Pharmacokinetics of Three Oximes in a Guinea Pig Model and Efficacy of Combined Oxime Therapy
Sara Bohnert et al.
TOXICOLOGY LETTERS (2020)
Biomedical potentialities of cationic geminis as modulating agents of liposome in drug delivery across biological barriers and cellular uptake
Rais V. Pavlov et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)
Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus
Mary B. Dail et al.
TOXICOLOGICAL SCIENCES (2019)
The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime
Dietrich E. Lorke et al.
FRONTIERS IN NEUROSCIENCE (2019)
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Ondrej Soukup et al.
MEDICINAL CHEMISTRY (2018)
How to defeat a nerve agent
Richard Stone
SCIENCE (2018)
The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation
Nikolina Macek Hrvat et al.
TOXICOLOGY LETTERS (2018)
Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques
Yvonne J. Rosenberg et al.
TOXICOLOGY LETTERS (2018)
Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
Gianluca Santoni et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Predicting a Drug's Membrane Permeability: A Computational Model Validated With in Vitro Permeability Assay Data
Brian J. Bennion et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2017)
The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs
Michael A. Malfatti et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2017)
Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor
Yvonne J. Rosenberg et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2017)
Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity
Tatiana N. Pashirova et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates
Janice E. Chambers et al.
COUNTERMEASURES AGAINST CHEMICAL THREATS (2016)
Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX
Janice E. Chambers et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2016)
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents
C. Linn Cadieux et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2016)
Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6
Anders Allgardsson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates
Janice E. Chambers et al.
TOXICOLOGY (2016)
Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics
Jamal Chauhan et al.
PLOS ONE (2016)
Large-Scale First-Principles Molecular Dynamics Simulations with Electrostatic Embedding: Application to Acetylcholinesterase Catalysis
Jean-Luc Fattebert et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
A Wrench in the Works of Human Acetylcholinesterase: Soman Induced Conformational Changes Revealed by Molecular Dynamics Simulations
Brian J. Bennion et al.
PLOS ONE (2015)
A Method to Predict Blood-Brain Barrier Permeability of Drug-Like Compounds Using Molecular Dynamics Simulations
Timothy S. Carpenter et al.
BIOPHYSICAL JOURNAL (2014)
Preclinical Studies of Noncharged Oxime Reactivators for Organophosphate Exposure
Karl J. Okolotowicz et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2014)
Toward Fully Automated High Performance Computing Drug Discovery: A Massively Parallel Virtual Screening Pipeline for Docking and Molecular Mechanics/Generalized Born Surface Area Rescoring to Improve Enrichment
Xiaohua Zhang et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)
Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification
Rakesh K. Sit et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Syrian gas attack reinforces need for better anti-sarin drugs
Elie Dolgin
NATURE MEDICINE (2013)
Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
Zoran Radic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Synthesis and In Vitro and In Vivo Inhibition Potencies of Highly Relevant Nerve Agent Surrogates
Edward C. Meek et al.
TOXICOLOGICAL SCIENCES (2012)
New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
Rakesh K. Sit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Amidine-Oximes: Reactivators for Organophosphate Exposure
Jaroslaw Kalisiak et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Butyrylcholinesterase and G116H, G116S, G117H, G117N, E197Q and G117H/E197Q mutants: A molecular dynamics study
Shubham Vyas et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Reaction profiles of the interaction between sarin and acetylcholinesterase and the S203C mutant: Model nucleophiles and QM/MM potential energy surfaces
Jeremy M. Beck et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4 A modified kinetic approach
Franz Worek et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)
Analysis of Pralidoxime in Serum, Brain and CSF of Rats
Huba Kalasz et al.
MEDICINAL CHEMISTRY (2009)
A novel design of artificial membrane for improving the PAMPA model
Xiaoxi Chen et al.
PHARMACEUTICAL RESEARCH (2008)
In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system
Bo Feng et al.
DRUG METABOLISM AND DISPOSITION (2008)
Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase
N. Aurbek et al.
TOXICOLOGY (2006)
Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry
SK Balani et al.
DRUG METABOLISM AND DISPOSITION (2006)
History of chemical and biological warfare agents
L Szinicz
TOXICOLOGY (2005)
Drug resistance in brain diseases and the role of drug efflux transporters
W Löscher et al.
NATURE REVIEWS NEUROSCIENCE (2005)
Permeability studies on in vitro blood-brain barrier models: Physiology, pathology, and pharmacology
MA Deli et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2005)
Pralidoxime iodide (2-PAM) penetrates across the blood-brain barrier
K Sakurada et al.
NEUROCHEMICAL RESEARCH (2003)
A high-throughput method for the conversion of CO2 obtained from biochemical samples to graphite in septa-sealed vials for quantification of 14C via accelerator mass spectrometry
TJ Ognibene et al.
ANALYTICAL CHEMISTRY (2003)
Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase
K Tai et al.
BIOPHYSICAL JOURNAL (2001)
Share Paper
