Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis

Multiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in our previous study. In this study, we examined whether the reduction in GLP-1 secretory capacity is associated with increased extent of coronary artery stenosis in non-diabetic patients. Non-diabetic patients who were admitted for coronary angiography without a history of coronary interventions were enrolled. Coronary artery stenosis was quantified by Gensini score (GS), and GS >= 10 was used as an outcome variable based on its predictive value for cardiovascular events. The patients (mean age, 66.5 +/- 8.8 years; 71% males, n=173) underwent oral 75 g-glucose tolerant tests for determination of glucose, insulin and active GLP-1 levels. The area under the curve of plasma active GLP-1 (AUC-GLP-1) was determined as an index of GLP-1 secretory capacity. AUC-GLP-1 was not correlated with fasting glucose, AUC-glucose, serum lipids or indices of insulin sensitivity. In multivariate logistic regression analysis for GS >= 10, AUC-GLP-1

Automated summary

The study examined the phenomenon of blunted GLP-1 secretion in apparently healthy subjects and its potential association with increased extent of coronary artery stenosis in non-diabetic patients. It was found that GLP-1 secretory capacity was not correlated with fasting glucose, glucose under the curve, serum lipids, or insulin sensitivity indices.