Journal
GENES & DEVELOPMENT
Volume 30, Issue 14, Pages 1589-1597Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.284091.116
Keywords
immune; metabolites; microbiome
Categories
Funding
- Yael and Rami Ungar, Israel
- Gurwin Family Fund for Scientific Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Crown Endowment Fund for Immunological Research
- estate of Jack Gitlitz
- estate of Lydia Hershkovich
- Benoziyo Endowment Fund for the Advancement of Science
- Adelis Foundation
- Pacific Palisades
- Alan Markovitz, Canada
- Cynthia Adelson, Canada
- Centre National de la Recherche Scientifique (CNRS)
- estate of Samuel and Alwyn J. Weber
- Mr. and Mrs. Donald L. Schwarz, Sherman Oaks
- European Research Council
- Kenneth Rainin Foundation
- German-Israel Binational Foundation
- Israel Science Foundation
- Minerva Foundation
- Rising Tide foundation
- Alon Foundation scholar award
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The mammalian intestine harbors one of the largest microbial densities on Earth, necessitating the implementation of control mechanisms by which the host evaluates the state of microbial colonization and reacts to deviations from homeostasis. While microbial recognition by the innate immune system has been firmly established as an efficient means by which the host evaluates microbial presence, recent work has uncovered a central role for bacterial metabolites in the orchestration of the host immune response. In this review, we highlight examples of how microbiota-modulated metabolites control the development, differentiation, and activity of the immune system and classify them into functional categories that illustrate the spectrum of ways by which microbial metabolites influence host physiology. A comprehensive understanding of how microbiota-derived metabolites shape the human immune system is critical for the rational design of therapies for microbiota-driven diseases.
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