A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis

HLA-B*52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3 (rs103294) were newly identified as non-HLA susceptibility loci in TAK. Here, we examined how these SNPs contribute to clinical characteristics and vascular damage in TAK. We retrospectively reviewed the medical records of 99 TAK patients enrolled in our previous genome-wide association study, and whose genotypes for IL12B rs6871626, LILRA3 rs103294, and HLA-B*52 were available. Incidence of aortic regurgitation (AR) was significantly associated with the A allele (risk allele) of IL12B rs6871626 (CC 42%, AC 61%, AA 81%; p = 0.0052; odds ratio [OR] 2.45), as well as with the incidence of hypertension (p = 0.049; OR 1.82) and the proportion of patients who underwent aortic valve replacement (p = 0.023; OR 3.64). Regarding vascular damage, there was positive correlation between the Takayasu Arteritis Damage Score and the A allele of IL12B rs6871626 (CC 3.42 +/- 2.71, AC 4.06 +/- 3.25, AA 6.00 +/- 2.81; p = 0.0035; beta = 1.35) and between the Vasculitis Damage Index and the A allele (CC 3.47 +/- 1.98, AC 4.33 +/- 2.40, AA 5.37 +/- 2.22; p = 0.0054; beta = 0.96). Contrarily, no correlation was found between LILRA3 rs103294 and vascular damage. In the present study, IL12B rs6871626 was associated with vascular damage in TAK, whereas LILRA3 rs103294 was not. Genotyping of IL12B rs6871626 may help to identify patients at risk of disease progression.

Automated summary

In TAK, IL12B rs6871626 A allele is significantly associated with aortic regurgitation, hypertension, aortic valve replacement, and vascular damage scores, while LILRA3 rs103294 shows no correlation with vascular damage. Genotyping of IL12B rs6871626 may help identify TAK patients at risk of disease progression.