Lung-to-finger circulation time can be measured stably with high reproducibility by simple breath holding method in cardiac patients

Lung to finger circulation time (LFCT) has been used to estimate cardiac function. We developed a new LFCT measurement device using a laser sensor at fingertip. We measured LFCT by measuring time from re-breathing after 20 s of breath hold to the nadir of the difference of transmitted red light and infrared light, which corresponds to percutaneous oxygen saturation. Fifty patients with heart failure were enrolled. The intrasubject stability of the measurement was assessed by the intraclass correlation coefficient (ICC). The ICC calculated from 44 cases was 0.85 (95% confidence interval: 0.77-0.91), which means to have Excellent reliability. By measuring twice, at least one clear LFCT value was obtained in 89.1% of patients and the overall measurability was 95.7%. We conducted all LFCT measurements safely. High ICCs were obtained even after dividing patients according to age, cardiac index (CI); 0.85 and 0.84 (>= 75 or<75 years group, respectively), 0.81 and 0.84 (N=26,or<2.2 L/min/M-2). These results show that our new method to measure LFCT is highly stable and feasible for any type of heart failure patients.

Automated summary

The new method to measure LFCT is highly stable and feasible for any type of heart failure patients, achieving excellent reliability with an ICC of 0.85. The overall measurability reached 95.7% in the study, demonstrating the efficacy and safety of the device.