Perioperative hemodynamic instability in pheochromocytoma and sympathetic paraganglioma patients

For pheochromocytoma and sympathetic paraganglioma (PPGL), surgery can be used as a curative treatment; however, the life-threatening risk of perioperative hemodynamic instability (HI) presents challenges. This study aimed to analyze the incidence and predictive factors of perioperative HI. The electronic medical records of 114 consecutive patients who underwent surgery for PPGLs at our institution were retrospectively reviewed. HI was defined as one or more episodes of systolic blood pressure > 200 mmHg or mean blood pressure < 60 mmHg during surgery. The factors predictive of perioperative HI were determined using both univariate and multivariate analyses. Intraoperative HI occurred in 79 (69.3%) patients. In multivariate analysis, alpha-adrenergic receptor blocker duration (days) (odds ratio, 1.015; 95% confidence interval, 1.001-1.029) was a predictor for intraoperative HI. Postoperative hypotension occurred in 36 (31.6%) patients. Higher urine epinephrine levels, and greater preoperative highest heart rate (HR) were predictive factors for postoperative hypotension in PPGL patients. Caution should be taken in perioperative management for PPGL, especially with long duration of alpha-adrenergic receptor blocker use, higher urine epinephrine levels, and greater preoperative highest HR.

Automated summary

Surgery for PPGL can be curative, but the perioperative period poses challenges due to the risk of hemodynamic instability. Factors such as duration of alpha-adrenergic receptor blocker use, urine epinephrine levels, and preoperative heart rate can predict intraoperative and postoperative hemodynamic instability in PPGL patients, requiring caution in perioperative management.