An ALE meta-analytical review of the neural correlates of abstract and concrete words

Several clinical studies have reported a double dissociation between abstract and concrete concepts, suggesting that they are processed by at least partly different networks in the brain. However, neuroimaging data seem not in line with neuropsychological reports. Using the ALE method, we run a meta-analysis on 32 brain-activation imaging studies that considered only nouns and verbs. Five clusters were associated with concrete words, four clusters with abstract words. When only nouns were selected three left activation clusters were found to be associated with concrete stimuli and only one with abstract nouns (left IFG). These results confirm that concrete and abstract words processing involves at least partially segregated brain areas, the IFG being relevant for abstract nouns and verbs while more posterior temporoparietal-occipital regions seem to be crucial for processing concrete words, in contrast with the neuropsychological literature that suggests a temporal anterior involvement for concrete words. We investigated the possible reasons that produce different outcomes in neuroimaging and clinical studies.

Automated summary

Multiple clinical studies have indicated a double dissociation between abstract and concrete concepts in brain processing, with neuroimaging data not entirely aligning with these reports. This meta-analysis of brain activation imaging studies revealed distinct brain areas associated with processing concrete and abstract words, suggesting segregated neural networks for different types of concepts. This highlights the discrepancy between neuroimaging and clinical studies in understanding the neural mechanisms underlying abstract and concrete word processing.