Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-94206-4
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Funding
- National Health and Medical Research Council of Australia [572613, 403981, 1059711, 1027449, 1044840, 1021858]
- Canadian Institutes of Health Research [MOP-82893]
- WA Health, Government of Western Australia (WADOH) [Future Health WA] [WA G06302]
- Safe Work Australia
- NHMRC
- The University of Western Australia (UWA)
- Curtin University
- Women and Infants Research Foundation
- Telethon Kids Institute
- Edith Cowan University
- Murdoch University
- The University of Notre Dame Australia
- The Raine Medical Research Foundation
- Australian Government
- Government of Western Australia
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The study highlights the importance of genetics, early life nutrition, and their interaction in adult health. Longer duration of breastfeeding is beneficial for all individuals, and particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher birthweight polygenic scores.
It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and the interaction between them, on optimal adult health. As part of a large international consortium (n similar to 154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based on the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.
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