Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41598-021-92042-0
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Funding
- Medical Research Council [MC_UU_00022/4, MC_UU_12017/10] Funding Source: Medline
- Chief Scientist Office [SPHSU10, PCL/21/03, SPHSU19] Funding Source: Medline
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The study reveals a correlation between the composition of blood microbiota and an individual's biological age. Individuals with a higher biological age have a higher abundance of pathogenic bacteria in their circulation, while those with a lower biological age possess more bacteria beneficial to human health. In individuals with lower socioeconomic status, lower betaine levels indicate poorer dietary habits and health conditions.
Imbalanced nutrition is associated with accelerated ageing, possibly mediated by microbiota. An analysis of the circulatory microbiota obtained from the leukocytes of participants in the MRC Twenty-07 general population cohort was performed. We now report that in this cohort, the most biologically aged exhibit a significantly higher abundance of circulatory pathogenic bacteria, including Neisseria, Rothia and Porphyromonas, while those less biologically aged possess more circulatory salutogenic (defined as being supportive of human health and wellbeing) bacteria, including Lactobacillus, Lachnospiraceae UCG-004 and Kocuria. The presence of these salutogenic bactreria is consistent with a capacity to metabolise and produce Nrf2 agonists. We also demonstrate that associated one carbon metabolism, notably betaine levels, did not vary with chronological age, but displayed a difference with socioeconomic position (SEP). Those at lower SEP possessed significantly lower betaine levels indicative of a poorer diet and poorer health span and consistent with reduced global DNA methylation levels in this group. Our data suggest a clear route to improving age related health and resilience based on dietary modulation of the microbiota.
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