Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop

The incidence of metabolic and chronic diseases including cancer, obesity, inflammation-related diseases sharply increased in the 21st century. Major underlying causes for these diseases are inflammation and oxidative stress. Accordingly, natural products and their bioactive components are obvious therapeutic agents for these diseases, given their antioxidant and anti-inflammatory properties. Research in this area has been significantly expanded to include chemical identification of these compounds using advanced analytical techniques, determining their mechanism of action, food fortification and supplement development, and enhancing their bioavailability and bioactivity using nanotechnology. These timely topics were discussed at the 20th Frontier Scientists Workshop sponsored by the Korean Academy of Science and Technology, held at the University of Hawaii at Manoa on 23 November 2019. Scientists from South Korea and the U.S. shared their recent research under the overarching theme of Bioactive Compounds, Nanoparticles, and Disease Prevention. This review summarizes presentations at the workshop to provide current knowledge of the role of natural products in the prevention and treatment of metabolic diseases.

Automated summary

In the 21st century, the incidence of metabolic and chronic diseases, such as cancer, obesity, and inflammation-related diseases, has sharply increased, with inflammation and oxidative stress being major underlying causes. Natural products and their bioactive components are increasingly recognized as promising therapeutic agents for these diseases due to their antioxidant and anti-inflammatory properties. Research in this area has expanded significantly to include chemical identification, mechanism of action determination, food fortification, supplement development, and enhancing bioavailability and bioactivity through nanotechnology.