Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review

Colostrum is the first secretion of mammalian glands during the early period after birth giving. Its components are biologically active and have beneficial effects on new-born growth and well-being. Bovine colostrum has the highest concentration of these substances and its supplementation or application may provide health benefits. This systematic review was conducted to update current knowledge on bovine colostrum effects including all administration routes on healthy and sick subjects. Full texts or abstracts of twenty-eight papers as reports of systematic reviews, randomized controlled trials, observational studies and case series were included after searches in Medline, Embase, Cochrane Library and Cinahl databases. The full texts of selected studies were assessed for quality using validated tools and their results were summarized in different categories. Studies were highly heterogeneous as regards to population, intervention, outcome and risk of bias. Bovine colostrum topical application was shown effective on vaginal dryness related symptoms limitation. Its use as food supplement showed interesting effects preventing upper respiratory illness in sportsmen, modulating immune system response and reducing intestinal permeability in healthy and sick subjects. Conflicting results were provided in pediatric population and little evidence is available on its use with older adults. Further studies are mandatory to better understand all factors influencing its activity.

Automated summary

Colostrum is the first secretion of mammalian glands after birth, containing biologically active components beneficial for new-borns. Bovine colostrum, with its high concentration of these substances, can be applied topically or as a food supplement to provide health benefits. The effects of bovine colostrum vary in different populations, with evidence of effectiveness in certain areas such as relieving vaginal dryness symptoms, preventing upper respiratory illness in sportsmen, and modulating immune system response. Further research is needed to fully understand the factors influencing its activity.