Journal
NUTRIENTS
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/nu13082595
Keywords
cytokines; dysbiosis; glucose metabolism; lipid metabolism; microbiota; obesity; organosulfur compound
Categories
Funding
- FEDER-INNTERCONECTA-CDTI program (CDTI, Centre for the Development of Industrial Technology) [ITC-20181038]
- Junta de Andalucia [CTS 164]
- Instituto de Salud Carlos III [PI19/01058]
- European Union
- Instituto de Salud Carlos III
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The study found that propyl propane thiosulfonate (PTSO) helps reduce weight gain, improve plasma markers, and attenuate obesity-associated inflammation, improving gut barrier integrity.
Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Methods and results: Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesity-associated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1 beta, Il-6, Tnf-alpha, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-alpha, Ppar-gamma, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.
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