Journal
NUTRIENTS
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/nu13082513
Keywords
soy; prospective study; diabetes; cardiovascular disease; mortality
Categories
Funding
- British Heart Foundation
- Cancer Research UK
- Chinese Ministry of Science and Technology
- Kadoorie Charitable Foundation in Hong Kong
- Medical Research Council UK
- Wellcome Trust
- Chinese National Natural Science Foundation
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Randomized controlled trials have shown that consuming soy can significantly reduce the risk of cardiovascular death among individuals with diabetes. A study in Chinese adults with diabetes found that higher soy consumption was associated with a lower risk of cardiovascular death, especially from coronary heart disease and acute myocardial infarction.
Randomized controlled trials showed that soy intervention significantly improved blood lipids in people with diabetes. We sought to prospectively examine the association of soy consumption with the risk of cardiovascular death among individuals with diabetes. A total of 26,139 participants with a history of diabetes were selected from the Chinese Kadoorie Biobank study. Soy food consumption was assessed by a food frequency questionnaire. Causes of death were coded by the 10th International Classification of Diseases. The Cox proportional hazard regression was used to compute the hazard ratios. During a median follow-up of 7.8 years, a total of 1626 deaths from cardiovascular disease (CVD) were recorded. Compared with individuals who never consumed soy foods, the multivariable-adjusted risks (95% confidence intervals) of CVD mortality were 0.92 (0.78, 1.09), 0.89 (0.75, 1.05), and 0.77 (0.62, 0.96) for those who consumed soy foods monthly, 1-3 days/week, and >= 4 days/week, respectively. For cause-specific cardiovascular mortality, significant inverse associations were observed for coronary heart disease and acute myocardial infarction. Higher soy food consumption was associated with a lower risk of cardiovascular death, especially death from coronary heart disease and acute myocardial infarction, in Chinese adults with diabetes.
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