Journal
NUTRIENTS
Volume 13, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/nu13072361
Keywords
fatty acids; fish oil; bone density; chronic kidney disease-mineral and bone disorder; kidney transplantation; osteoporosis
Categories
Funding
- South-Eastern Norway Regional Health Authority
- Gidske and Peter Jacob Sorensen Research Fund
- Norwegian National Association for Kidney Patients and Transplant Recipients Research Fund
- Raagholt Foundation
- Freia Corporation Medical Fund
- Nathalia and Knut Juul Christensen Research Fund
- Signe and Albert Bergsmarken Research Fund
- Gertrude and Jack Nelsons Research Fund
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The study did not find a significant effect of 44 weeks of supplementation with 2.6 g of marine n-3 PUFA on bone mineral density (BMD) in kidney transplant recipients.
Kidney transplant recipients are at high risk of progressive bone loss and low-energy fractures in the years following transplantation. Marine n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation may have beneficial effects on bone strength. The Omega-3 fatty acids in Renal Transplantation (ORENTRA) trial was an investigator initiated, randomized, placebo-controlled trial investigating the effects of marine n-3 PUFA supplementation after kidney transplantation. Effects of supplementation on bone mineral density (BMD) and calcium metabolism were pre-defined secondary endpoints. Adult kidney transplant recipients (n = 132) were randomized to 2.6 g marine n-3 PUFA supplement or olive oil (control) from 8 to 52 weeks post-transplant. Dual energy X-ray absorptiometry was performed to assess changes in bone mineral density of hip, spine, and forearm, as well as trabecular bone score (TBS) of the lumbar spine. Student's t test was used to assess between-group differences. There were no differences in Delta BMD between the two groups (intervention vs. control) at lumbar spine (-0.020 +/- 0.08 vs. -0.007 +/- 0.07 g/cm(2), p = 0.34), total hip (0.001 +/- 0.03 vs. -0.005 +/- 0.04, p = 0.38), or other skeletal sites in the intention-to-treat analyses. There was no difference in the change in TBS score (0.001 +/- 0.096 vs. 0.009 +/- 0.102, p = 0.62). Finally, no effect on biochemical parameters of mineral metabolism was seen. Results were similar when analyzed per protocol. In conclusion, we found no significant effect of 44 weeks of supplementation with 2.6 g of marine n-3 PUFA on BMD in kidney transplant recipients.
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