Journal
NUTRIENTS
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/nu13082643
Keywords
reverse cholesterol transport; HDL; fatty acids; sterols; rodents
Categories
Funding
- Instituto de Salud Carlos III
- FEDER Una manera de hacer Europa Miguel Servet Type 2 contract [CPII18/00004]
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Reverse cholesterol transport is a physiological mechanism that protects cells from excessive cholesterol accumulation, while dietary lipids may have detrimental effects on cardiovascular health. This review summarizes the mechanisms of action of different types of dietary lipids on various steps of RCT and provides a critical analysis of data from experimental models to clarify their effects on cardiovascular disease.
Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease.
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