Journal
NUTRIENTS
Volume 13, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/nu13072448
Keywords
asiatic acid; atopic dermatitis; anti-inflammatory; immunomodulatory
Categories
Funding
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the Agri-Bio Industry Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [319104-04-1-HD030]
- Ministry of Agriculture, Food, and Rural Affairs
- Korea Food Research Institute [G0190300-01]
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The study demonstrated that asiatic acid has immunomodulatory and anti-inflammatory effects on atopic dermatitis, reducing skin lesions formation and decreasing the expression levels of related proteins and genes.
We examined the immunomodulatory and anti-inflammatory effects of asiatic acid (AA) in atopic dermatitis (AD). AA treatment (5-20 mu g/mL) dose-dependently suppressed the tumor necrosis factor (TNF)-alpha level and interleukin (IL)-6 protein expression in interferon (IFN)-gamma + TNF-alpha-treated HaCaT cells. The 2,4-dinitrocholrlbenzene (DNCB)-induced AD animal model was developed by administering two AA concentrations (30 and 75 mg/kg/d: AD + AA-L and AD + AA-H groups, respectively) for 18 days. Interestingly, AA treatment decreased AD skin lesions formation and affected other AD characteristics, such as increased ear thickness, lymph node and spleen size, dermal and epidermal thickness, collagen deposition, and mast cell infiltration in dorsal skin. In addition, in the DNCB-induced AD animal model, AA treatment downregulated the mRNA expression level of AD-related cytokines, such as Th1- (TNF-alpha and IL-1 beta and -12) and Th2 (IL-4, -5, -6, -13, and -31)-related cytokines as well as that of cyclooxygenase-2 and CXCL9. Moreover, in the AA treatment group, the protein level of inflammatory cytokines, including COX-2, IL-6, TNF-alpha, and IL-8, as well as the NF-kappa B and MAPK signaling pathways, were decreased. Overall, our study confirmed that AA administration inhibited AD skin lesion formation via enhancing immunomodulation and inhibiting inflammation. Thus, AA can be used as palliative medication for regulating AD symptoms.
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