Journal
NUTRIENTS
Volume 13, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/nu13092926
Keywords
rice bran; Superjami; postmenopause; bone metabolism; oxidative stress; aging
Categories
Funding
- Bio Green 21 Program [PJ011089]
- Rural Development Administration, Republic of Korea
Ask authors/readers for more resources
The study found that adding extracts from dark purple Superjami rice bran can alleviate bone loss and oxidative stress in menopause-induced animal models, helping to prevent postmenopausal osteoporosis and oxidative damage.
Menopause is a matter of concern for women's health due to a deficiency of female hormones; additionally, reactive oxygen species and aging can cause osteoporosis. Food becomes increasingly interesting as a menopausal woman's alternative to hormone therapy. The effects of ethanol extracts from dark purple Superjami rice bran on bone metabolism and antioxidant defense systems in menopause-induced animal models were evaluated. Female rats underwent sham surgery or were ovariectomized to induce a menopause-like state. Rats were divided into a sham control group (SHAM), an ovariectomized control group (OVX), and an ovariectomized grou supplemented with Superjami rice bran extract group (OVX-S) and fed for 8 weeks. The OVX groups exhibited significantly more weight gain, amounts of bone turnover biochemical markers (alkaline phosphatase, osteocalcin, and C-terminal telopeptide), bone loss, lipid-peroxidation and oxidative stress than the SHAM group. However, Superjami bran extract added to the diet resulted in a significant reduction in body weight and lipid peroxidation, as well as enhanced bone metabolism and antioxidant enzyme activities, in ovariectomized rats. These results propound that extracts from Superjami rice bran have therapeutic potentiality against bone loss and oxidative stress in menopause-induced states and will be useful in preventing postmenopausal osteoporosis and oxidative damage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available