Journal
NUTRIENTS
Volume 13, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/nu13072150
Keywords
punicalagin; ellagic acid; apoptosis; proliferation; immune cells; metabolism
Categories
Funding
- Ministry of Education, Youth and Sport of the Czech Republic [8X20023]
- Ministry of Education, Science, Research and Sport of the Slovak Republic projects [APVV-18-0312, DS-FR-19-0049]
- Mendel University in Brno
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Punicalagin, a polyphenol found in pomegranate peel, has antioxidant, anti-inflammatory, anti-tumor activities, as well as hepatoprotective and anti-atherosclerotic effects.
The aim of this publication is to compile a summary of the findings regarding punicalagin in various tissues described thus far in the literature, with an emphasis on the effect of this substance on immune reactions. Punicalagin (PUN) is an ellagitannin found in the peel of pomegranate (Punica granatum). It is a polyphenol with proven antioxidant, hepatoprotective, anti-atherosclerotic and chemopreventive activities, antiproliferative activity against tumor cells; it inhibits inflammatory pathways and the action of toxic substances, and is highly tolerated. This work describes the source, metabolism, functions and effects of punicalagin, its derivatives and metabolites. Furthermore, its anti-inflammatory and antioxidant effects are described.
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