Diet, Microbiome, and Cancer Immunotherapy-A Comprehensive Review

The immune system plays a key role in cancer suppression. Immunotherapy is widely used as a treatment method in patients with various types of cancer. Immune checkpoint blockade using antibodies, such as anti-PD-1, anti-PD-L1, and anti-CTLA-4, is currently gaining popularity. A systematic literature search was executed, and all available data was summarized. This review shows that specific dietary patterns (such as, e.g., animal-based, vegetarian, or Mediterranean diet) alter the gut microbiome's composition. An appropriate intestinal microbiota structure might modulate the function of human immune system, which affects the bodily anti-cancer response. This paper shows also that specific bacteria species inhabiting the gastrointestinal tract can have a beneficial influence on the efficacy of immunotherapy. Antibiotics weaken gut bacteria and worsen the immune checkpoint blockers' efficacy, whereas a faecal microbiota transplant or probiotics supplementation may help restore bacterial balance in the intestine. Other factors (like vitamins, glucose, or BMI) change the cancer treatment response, as well. This review demonstrates that there is a strong association between one's diet, gut microbiome composition, and the outcome of immunotherapy. However, further investigation on this subject is required.

Automated summary

The immune system plays a crucial role in cancer suppression, with immunotherapy being a widely used treatment method. The gut microbiome composition can be altered by specific dietary patterns, affecting the human immune system and anti-cancer response. Specific bacteria in the gastrointestinal tract can influence the efficacy of immunotherapy, and factors like antibiotics, fecal microbiota transplant, and probiotics supplementation play a role in restoring bacterial balance and treatment outcomes. Further research is needed to fully understand the relationship between diet, gut microbiome, and immunotherapy outcomes.